Figure 1
From: Peptide-substituted oligonucleotide synthesis and non-toxic, passive cell delivery
Synthetic strategy for TP ODNs having lysine or peptide-substituted 1,2,3-triazolylphosphonate internucleotide linkages. This solid-phase synthesis procedure introduces an alkynyl group at any desired position within the ODN backbone. B*=N6-benzoyladenine, N4-acetylcytosine, N2-isobutyroylguanine or thymine; B=adenine, cytosine, guanine or thymine.
