Table 1 TP ODNs: sequences, molecular weight analysis and net charge at pH 7.4
From: Peptide-substituted oligonucleotide synthesis and non-toxic, passive cell delivery
TP ODN | Sequence | Molecular weight | Net charge | |
|---|---|---|---|---|
Calculated | Observed | |||
4K | 5′-TLysGTAALysACCLysATGATGTGCTGCTLysA-3′ | 7469.8 | 7468.3 | −17 |
6K | 5′-TLysGTAAALysCLysCLysALysTGATGTGCTGCTLysA-3′ | 7830.0 | 7828.9 | −15 |
4GR | 5′-TGRGTAAGRACCGRATGATGTGCTGCTGRA-3′ | 7806.0 | 7804.9 | −13 |
6GR | 5′-TGRGTAAAGRCGRCGRAGRTGATGTGCTGCTGRA-3′ | 8334.3 | 8333.8 | −9 |
2PA | 5′-TPepAGTAAACCATGATGTGCTGCTPepAA-3′ | 8130.3 | 8128.5 | −13 |
3PA | 5′ -TPepAGTAAACCAPepATGATGTGCTGCTPepAA-3′ | 8820.6 | 8820.4 | −9 |
2PG | 5′-TPepGGTAAACCATGATGTGCTGCTPepGA-3′ | 8252.3 | 8251.7 | −13 |
3PG | 5′ -TPepGGTAAACCAPepGTGATGTGCTGCTPepGA-3′ | 8988.8 | 8988.4 | −9 |
2PJ | 5′-TPepJGTAAACCATGATGTGCTGCTPepJA-3′ | 8526.4 | 8524.9 | −9 |
3PJ | 5′-TPepJGTAAACCAPepJTGATGTGCTGCTPepJA-3′ | 9414.9 | 9414.7 | −3 |
