Table 3 Sequences of the TP ODNs studied in the luciferase assay

From: Peptide-substituted oligonucleotide synthesis and non-toxic, passive cell delivery

Oligo

Sequence

Net charge

4K

5′-TLysGTAALysACCLysATGATGTGCTGCTLysA-3′

−17

6K

5′-TLysGTAAALysCLysCLysALysTGATGTGCTGCTLysA-3′

−15

2PB

5′-TPepBGTAAACCATGATGTGCTGCTPepBA-3′

−13

3PB

5′ -TPepBGTAAACPepBCATGATGTGCTGCTPepBA-3′

−9

4PB

5′-TPepBGTAPepBAACCPepBATGATGTGCTGCTPepBA-3′

−5

2PK

5′-TPepKGTAAACCATGATGTGCTGCTPepKA-3′

−13

3PK

5′-TPepKGTAAACPepKCATGATGTGCTGCTPepKA-3′

−9

2PC

5′-TPepCGTAAACCATGATGTGCTGCTPepCA-3′

−11

3PC

5′ -TPepCGTAAACCAPepCTGATGTGCTGCTPepCA-3′

−6

2PG

5′-TPepGGTAAACCATGATGTGCTGCTPepGA-3′

−13

3PG

5′ -TPepGGTAAACCAPepGTGATGTGCTGCTPepGA-3′

−9

2PJ

5′-TPepJGTAAACCATGATGTGCTGCTPepJA-3′

−9

3PJ

5′-TPepJGTAAACCAPepJTGATGTGCTGCTPepJA-3′

−3

  1. Abbreviations: ACHN, acetylated N terminus; NH2, amidated C terminus; PepB, AcHN-Lys-Lys-Lys(N3)-Lys-Gly-NH2; PepK, N3-Gly-Arg-Arg-Arg-Gly-NH2; PepC, AcHN-Gly-Lys(N3)-Gly-Arg-Arg-Gly-Arg-Arg-Gly-NH2; PepG, AcHN-Lys(N3)-Arg-Arg-Arg-Gly-NH2; PepJ, AcHN-Lys(N3)-Lys-Lys-His-His-His-NH2; TP ODN, triazolylphosphonate oligodeoxynucleotide.
  2. These sequences are anti-miR oligonucleotides (AMOs) to miR-15b (see Figure 7).