Figure 5 | Signal Transduction and Targeted Therapy

Figure 5

From: Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an early phase IIa trial report

Figure 5

Responses of the special lesions to Chimeric Antigen Receptor-modified T-20 (CART-20) cells. (a) The skin lesions of patient UPN09 completely disappeared, and the disappearance lasted up to 10 months or more, despite continued splenomegaly. (b) The new lesions in the testes of patient UPN02 emerged at 6 months after infusion. (c) Immunohistochemical examination of a needle biopsy of lesions in the testis from patient UPN02 at 6 months after CART-20 cell infusion showed that the tumor cells were CD20+, CD3−, CD4−, and CD8−. (d) The CART-20 cells in the peripheral blood, cerebral spinal fluid (CSF) and the testis of patient UPN02 were measured by quantitative real-time-PCR at 6 months after CART-20 cell infusion. PB, peripheral blood cells.

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