Figure 1 | Signal Transduction and Targeted Therapy

Figure 1

From: A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity

Figure 1

Expression of PD-L1 and PD-1 in mouse tumor cells and human tissues. (a) PD-L1 expression on the surface of CT26 and B16-F10 tumor cells was detected by FACS. The black and red line represents isotype and PD-L1, respectively. (b) Immunofluorescence analysis of PD-L1 expression on CT26 and B16-F10 tumor cells. Scale bar, 50 μm. Nuclei and PD-L1 showed blue and red, respectively. (c) TMA (Tissue microarrays) analysis for PD-1 and PD-L1 expression in colon cancer and melanoma tissues by immunochemistry. n=20. Scale bar, 50 μm. (d) TMA staining results for PD-L1 were assessed by their grades (high positive, low positive and negative). Each tumor contains 20 cases. Statistical charts were shown in different colors. (e) TMA staining results for PD-1 were assessed by their grades (high positive, low positive and negative). Each tumor contains 20 cases. Statistical charts were shown in different colors.

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