Figure 4 | Signal Transduction and Targeted Therapy

Figure 4

From: A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity

Figure 4

Adoptive animal experiments in vivo. Splenic lymphocytes of all groups were isolated after the third immunization and injected i.v. (intravenously; 1×107 cells per mouse) into mice challenged with tumor. (a) Scheme of adoptive immunotherapy. (b) Tumor growth curve of C26 adoptive immunotherapy. Six-week-old C57BL/6 mice challenged with CT26 tumor (n=8), adoptive immunotherapy as (a). Data are representative of three experiments. (c) Tumor growth curve of B16-F10 adoptive immunotherapy (n=8). Data are representative of three experiments. (d) Kaplan–Meier survival analysis of C26 adoptive immunotherapy (n=8). Results are representative of three independent experiments. (e) Kaplan–Meier survival analysis of B16-F10 adoptive immunotherapy (n=8). Results are representative of three independent experiments.

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