Figure 5
From: The competing mini-dumbbell mechanism: new insights into CCTG repeat expansion
(a) In the uninterrupted CCTG repeat tract of DM2 patients, the mini-loop can shift in both directions, resulting in a more efficient escape from MMR. (b) In normal individuals, the presence of interrupting motifs in the CCTG repeat tract hinders the shifting of mini-loop. Thereby, the mini-loop can be recognized and removed more efficiently by MMR proteins.
