Figure 4
From: Mammary stem cells: angels or demons in mammary gland?
Schematic diagram of Cre-loxP system-based genetically modified mice using lineage-tracing assay to track cellular origin of cancer. The double dotted lines arrow unproved results. PIK3CA-targeted and/or TP53-deleted MaSCs with GFP labeling are supposed to generate a totally GFP+ mammary tumor with all the cells labeled by GFP.
