Figure 3

After 70% partial hepatectomy (PH), platelets harboring VEGF-A and SDF-1 are associated with VEGFR3⁺ LSECs. (a, b) Liver sections were stained with antibodies to CD41 (green), VEGF-A and SDF-1 (red), and VEGFR3 (gray). After PH, but not sham operation (Sham), CD41⁺SDF-1⁺VEGF-A⁺ platelets are associated with VEGFR3⁺ LSECs. Scale bar, 50 μm. (c, d) BrdU incorporation in hepatocyte (c) and liver mass restoration (d) in Thpo^−/− and WT mice at days 2 and 8 after PH, respectively. ^#P<0.05, compared to control group; N=5–8 mice per group.