Figure 1 | Signal Transduction and Targeted Therapy

Figure 1

From: Central role of lactate and proton in cancer cell resistance to glucose deprivation and its clinical translation

Figure 1

The enigma of quantitative relationship between glucose consumption and cell mass production in vivo. (a) In vitro, if glucose supply is not a problem, in 22 days culture, 5×104 cells would be increased to 5×104×244, equivalent of 1.0×109 g cell mass, by consuming 3.17×109 g glucose and generating 2.7×109 g lactate (85% glucose carbon). (b) In vivo, in 22 days, 5×104 cells produced a total tumor mass of 3 g, but the amount of glucose consumed and lactate generated by these cells over 22 days is not known. Thus, the in vivo quantitative relationship between glucose consumption and biomass production remains an enigma.

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