Figure 1 | Signal Transduction and Targeted Therapy

Figure 1

From: Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy

Figure 1

Increased HIF1α protein levels in human patients with untreated proliferative diabetic retinopathy (PDR). Fundus (top) and fluorescein angiographic images (bottom) of the retinae of patients without PDR (a), PDR patients who were untreated (b) and patients with PDR who underwent prior panretinal photocoagulation (PRP) laser treatment (c). Enzyme-linked immunosorbent assays on vitreous samples taken from each patient group determined that HIF1α protein levels were similar in the vitreous of both control patients and treated PDR patients, but significantly elevated (P<0.005) in PDR patients who were not treated at the time of analysis (d). N=4 patients without PDR, 3 patients with untreated PDR and 3 patients with PDR who underwent PRP laser treatment. Error bars represent s.d.’s.

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