Figure 5
Neovascularization and retinal degeneration in the PDR murine model. Hematoxylin and eosin (H&E)-stained pupil optic nerve sections from eight Chx10-cre; Vhlflox/flox mice. At 1 month of age, the mice displayed signs of iris neovascularization (arrow) and protein extravasation in the anterior chamber (arrowhead), a sign of vascular leakage (a). There was optic disc neovascularization (arrow) and fibrosis in the vitreous (b), retinal photoreceptor degeneration (arrow) and vitreoretinal membranes (arrowhead) (c). Tractional vitreoretinal membranes (arrowhead) and vitreous neovascularization (arrow) were observed (d). N=12 eyes. All mice displayed neovascular and retinal degenerative phenotypes.
