Figure 6 | Signal Transduction and Targeted Therapy

Figure 6

From: Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy

Figure 6

Loss of visual function in the PDR murine model. A representative electroretinogram (ERG) trace at 1 month of age for maximum scotopic rod–cone mixed visual function displayed a severely attenuated visual response in the Chx10-cre; Vhlflox/flox mutant mice (gray) compared with C57BL/6J wild-type control mice (black; a). Quantification of the ERG maximum scotopic a-wave amplitude (labeled in a) for a cohort of mice displayed a significant loss of a-wave amplitude in the Chx10-cre; Vhlflox/flox mice compared with C57BL6/J controls at both 1 month of age (P<0.0001) and 2 months of age (P<0.0011; b). Similarly, there was a significant loss of the b-wave visual function (labeled in a) for the Chx10-cre; Vhlflox/flox mice at both 1 month of age (P<0.0001) and 2 months of age (P<0.0001; c). N>5 mice per group for each time point analyzed. Error bars show s.d.’s.

Back to article page