Table 1 In vitro cytotoxicity of T-SA1–DM1 and T-SA2–DM1 (72 h exposure, IC50, nm)

From: Therapeutic potential of an anti-HER2 single chain antibody–DM1 conjugates for the treatment of HER2-positive cancer

Material

MCF-7

MDA-MB-231

SKOV3

SKBR-3

T-SA1

>1200

>1200

>1200

>1200

T-SA1–DM1

>1200

>750

3.18±0.49

1.05±0.03

T-SA2

>1200

>1200

>1200

>1200

T-SA2–DM1

>1200

>750

3.57±0.45

1.10±0.09