Figure 1 | Signal Transduction and Targeted Therapy

Figure 1

From: Let’s talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine

Figure 1

Protein transport across the endoplasmic reticulum membrane. Mechanism of (a) co-translational and (b) posttranslational transport of precursor proteins through the Sec61 channel. (c) Topological domains of Sec61α1/ß/γ, (d) Sec62 and (e) Sec63. We note that (i) Sec63 interacts with Sec62 involving a cluster of negatively charged amino-acid residues near the C terminus of Sec63 and positively charged cluster in the N-terminal domain of Sec62,43 (ii) Sec62 interacts with the N-terminal domain of Sec61α via its C-terminal domain,68 (iii) BiP can bind to ER luminal loop 7 of Sec61 α via its substrate-binding domain and mediated by the ATPase domain of BiP and the J-domain in the ER luminal loop of Sec63,53 (iv) Ca2+-CaM can bind to an IQ motif in the N-terminal domain of Sec61α64 and (v) LC3 can bind to a LIR motif in the C-terminal domain of Sec62.71 40S, 40S ribosome subunit; 60S, 60S ribosome subunit; SR, heterodimeric SRP receptor; SRP, signal recognition particle.

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