Figure 2 | Signal Transduction and Targeted Therapy

Figure 2

From: Let’s talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine

Figure 2

Regulation of Ca2+ homeostasis at the endoplasmic reticulum membrane and Sec62-mediated autophagy. (a) Regulation of Ca2+ efflux through the Sec61 channel. (b) Sec62-mediated autophagy. The red arrows in a indicate inhibitory effects on the passive Ca2+ efflux through the Sec61 channel. 40S, 40S ribosome subunit; 60S, 60S ribosome subunit; CaM, calmodulin; CALR, calreticulin; LC3, 1A/1B-light chain 3; SERCA, sarcoplasmic/endoplasmic reticulum Ca2+-ATPase.

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