Figure 4 | Signal Transduction and Targeted Therapy

Figure 4

From: Let’s talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine

Figure 4

Protein translocation complex as a target of bacterial toxins and small molecule therapeutics. Small molecules are written in italic and black letters; bacterial toxins in italic and green letters. The red arrows indicate inhibitory effects directed against the respective target structure. 40S, 40S ribosome subunit; 60S, 60S ribosome subunit; CaM, calmodulin; SERCA, sarcoplasmic/endoplasmic reticulum Ca2+-ATPase.

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