Figure 6 | Signal Transduction and Targeted Therapy

Figure 6

From: ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity

Figure 6

Clinical relevance of ASAP3 in gastric acidity. (a) Representative immunohistochemistry (IHC) staining images for ASAP3 in gastric mucosa tissue, with quantified acid content indicated on the bottom of each image. The scale bar representing 100 μm applies to all images. (b) Correlation between ASAP3 expression and basal gastric acid secretion. Insets show higher-magnification images of boxed regions. The expression of ASAP3 expression was determined by IHC of tissue specimens (n=90), and the gastric acid concentration of overnight-fasting patients was determined by titration. The R value for Pearson correlation analysis is indicated in the plot (P<0.0001). (c) The expression of ASAP3 determined by IHC was compared between Helicobacter pylori-negative cases wither with or without gastro-esophageal reflux disease (GERD)/reflux (*P<0.05, two-sided t-test). (d) High expression of ASAP3 (top 25%, Q1) associated with gastric ulcer in human. The heat map in upper panel shows the expression of ASAP3 and gastric ulcer in patients, and the lower panel shows the result of chi-square test.

Back to article page