Table 3 PFKFB3 in different cancer cell lines

From: Roles of PFKFB3 in cancer

Cancer cell type	Upstream effector	Possible mechanism	PFKFB3 expression level	Effect on cancer cell	Ref.
Breast cancer cells	Estradiol	Increased transcription of PFKFB3 by ER	↑	Survival, growth and metastases	²⁸
	Progestins	Increased transcription of PFKFB3 by PR ERK/RSK phosphorylation of PFKFB3	↑	Proliferation	²⁷
	AMPK	Phosphorylation of PFKFB3	—	Mitotic arrest survival	⁷⁵
	miR-206	Interaction with 3′UTR in PFKFB3 mRNA level	↓	Proliferation and migration inhibition	³⁶
Hela cells	stress stimuli	p38/MK2 pathway	↑	Adaptation to microenvironmental conditions	³³
	high ROS	S-glutathionylation of PFKFB3	—	ROS detoxification; cell survival and proliferation	⁴⁰
	MAPK14	Increased degradation of PFKFB3 by APC/C-Cdh1 and SCF	↓	Increased resistance to nutrient deprivation	⁴⁴
	siRNA	Silencing of PFKFB3 gene	↓	Cell cycle arrest at G1/S; Increased apoptosis; anchorage-independent growth	^{47, 52}
Pancreatic and gastric cancer cells	hypoxia	Increased transcription of PFKFB3 by HIF-1	↑	Proliferation and survival	⁷⁶
Colorectal cancer	IL-6	—	↑	Proliferation and migration	⁷⁷
Colon carcinoma cell lines		Phosphorylation PFKFB3	—	Cell proliferation	⁷⁸
	insulin	Increased transcription of PFKFB3	↑		³⁰
	siRNA	silencing of PFKFB3 gene	↓	Apoptosis	⁵³
Lung adenocarcinoma cells	siRNA	Silencing of PFKFB3 gene	↓	Decreased growth	¹⁹
Renal cancer cells	rasfonin	—	↑	Autophagy and apoptosis	⁷⁹
Myeloid lineage cells	JAK2/STAT5	Increased transcription of PFKFB3 by STAT5	↑	Increased Growth	⁸⁰
Leukemia U937 cells	high ROS	Reduced methylation of PFKFB3	—	Survive from oxidative stress	⁴¹
Acute myeloid leukemia cell lines	siRNA	Silencing of PFKFB3 gene	↓	Cell proliferation inhibition; apoptosis induction	⁸¹
DB-1 melanoma cells	low pH exposure	Phosphorylation PFKFB3	—	Tumorigenesis and treatment resistance	⁸²
Osteosarcoma cells	miR-26b	Interaction with 3′UTR in PFKFB3 mRNA level	↓	Proliferation, migration, invasion inhibition; apoptosis induction	^{37, 54}
Bladder cancer cell lines	3PO	Inhibition of PFKFB3	—	Reduced growth	⁸³
Malignant hematopoietic and adenocarcinoma cell lines	3PO	Inhibition of PFKFB3	—	Reduced growth	⁸⁴
Tongue cancer	3PO	Inhibition of PFKFB3	—	Proliferation inhibition, apoptosis	²⁹
Pancreas cancer	TGFβ1	Increased transcription of PFKFB3	↑	Invasion	⁵⁷
Gastric cancer cells	siRNA	Silencing of PFKFB3 gene	↓	Proliferation and migration inhibition	⁸⁵
	PFK15	Inhibition of PFKFB3	—	Cell cycle arrest; apoptosis; invasion inhibition	⁵⁵
Head and neck squamous cell carcinoma cell lines	PFK15	Inhibition of PFKFB3	—	Proliferation suppression; halted cell cycle progression; induced cell apoptosis	⁵⁶
Glioblastoma cells		—	↑(Induced)	Decreased growth rate, cell viability, anchorage-independent growth	^{10, 58}

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Table 3 PFKFB3 in different cancer cell lines

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