Figure 3
From: Fibromodulin reduces scar formation in adult cutaneous wounds by eliciting a fetal-like phenotype
FMOD administration altered the expression of TGFβ1-related genes during adult rat cutaneous wound healing. Expression of Tgfβ1 (a), Col1α1 (b), Col1α2 (c), Col3α1 (d), Mmp2 (e), Ctgf (f), and Actα2 (g) was compared between PBS (control) and 2.0 mg ml−1 FMOD-treated adult rat cutaneous wounds. Clustergram plot further indicated that FMOD diversely modulated the expression of TGFβ1-related genes during adult rat cutaneous wound healing (h). A two-sample t-test was used for statistical analysis. Data were normalized to unwounded skin (dashed lines), and are shown as mean±the standard deviation. N=3 wounds from 3 animals pooled for each sample (9 wounds from 9 animals in total). *P<0.05.
