Table 2 Synergism analysis for CNL and ibrutinib co-treatment in JVM-3 cells

From: STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia

CNL dose

Ibrutinib dose

Cell viability

Combination index

Effect

5 μM

1 μM

83%

0.81

Synergism

5 μM

2.5 μM

79%

0.66

Synergism

10 μM

1 μM

53%

0.53

Synergism

10 μM

2.5 μM

42%

0.38

Synergism

  1. Treatment with ibrutinib alone at 1 and 2.5 μM for 24 h did not affect cell viability. Twenty-four hours treatment with CNL at 5 and 10 μM reduced cell viability to 90% and 70%, respectively.
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