Figure 3 | Signal Transduction and Targeted Therapy

Figure 3

From: Sympathetic transmitters control thermogenic efficacy of brown adipocytes by modulating mitochondrial complex V

Figure 3

Sympathetic cotransmitter ATP enhances NE-induced thermogenic efficacy in BA. (a and b) Representative thermal images of BA before and after 0.1 μM NE and 10 μM ATP co-treatment, respectively. Scale bar, 20 μm. (c) 0.1 μM NE and 10 μM ATP-induced thermal responses in BA. Each colored trace represents the thermogenic response of a single BA (n=158). (d) The dynamic plots of MMP demonstrate that most BA show MMP depolarization after NE and ATP co-treatment. Each colored trace represents an MMP dynamic of a single BA (n=158). (e) Shows scatter plots of MMP depolarization percentage in 0.1 μM NE without (black) or with (red) ATP-treated experiments. NE and ATP co-treatment increases the percentage of MMP depolarization (72.8±13.3%) compared to NE treatment alone (55.6±16.1%). Error bars in the figure represent mean±s.d. (f) 0.1 μM NE without (black line, also in Figure 1h) or with (red line, n=158) 10 μM ATP-induced thermogenesis in BA. The blue line shows the control results of ATP treatment alone in BA (n=67). All data points in f represent mean±s.e.m.

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