Key Points
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Clinicians need to be aware that squamous cell carcinoma (SCC) can complicate dental implant patients.
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Prompt instigation of oral hygiene measures for inflamed peri-implant tissue is especially important in individuals with risk factors for SCC.
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There should be a low threshold for biopsy of persistent inflamed peri-implant tissue not responding to local oral hygiene measures in individuals at risk of SCC.
Abstract
Osseointegrated dental implants are increasingly used in the rehabilitation of the dental patient. They have a particular role in dental rehabilitation following treatment for oral cancer. Data is presented that suggests that, in the at risk patient, squamous cell carcinoma may develop in association with dental implants.
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References
Weischer T, Mohr C . Ten-year experience in oral implant rehabilitation of cancer patients: treatment concept and proposed criteria for success. Int J Oral Maxillofac Implants 1999; 14: 521–528.
Shaw R J, Sutton A F, Cawood J I et al. Oral rehabilitation after treatment for head and neck malignancy. Head Neck 2005; 27: 459–470.
Van der Meij E H, Mast H, van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients. Oral Oncol 2007; 43: 742–748.
Jovanovic A, van der Tol I G, Kostense P J et al. Second respiratory and upper digestive tract cancer following oral squamous cell carcinoma: oral oncology. Eur J Cancer 1994; 30B: 225–229.
Johnson N W, Ranasinghe A W, Warnakulasuriya K A A S . Potentially malignant lesions and conditions of the mouth and oropharynx: natural history – cellular and molecular markers of risk. Eur J Cancer Prev 1993; 2 (Suppl 2): 31–51.
Reibel J . Tobacco and oral diseases: update on the evidence with recommendations. Med Princ Pract 2003; 12: 22–32.
Bain C A, Moy P K . The association between the failure of dental implants and cigarette smoking. Int J Oral Maxillofac Implants 1993; 8: 609–615.
De Bruyn H, Collaret B . The effects of smoking on early implant failure. Clin Oral Implants Res 1994; 5: 260–264.
Lambert P M, Morris H F, Ochi S . The influence of smoking on 3-year clinical success of osseointegrated dental implants. Ann Periodontol 2000; 5: 79–89.
Schartz-Arad D, Samet N, Samet N, Mamlider A . Smoking and complications of endosseous dental implants. J Periodontol 2002; 73: 153–157.
Galindo-Moreno P, Fauri M, Avila-Ortiz G, Fernandez-Barbero J E, Cabrera-Leon A, Sanchez-Fernandez E. Influence of alcohol and tobacco habits on peri-implant marginal bone loss: a prospective study. Clin Oral Implants Res 2005; 16: 579–586.
DeLuca S, Zarb G . The effect of smoking on osseointegrated dental implants. Part II: peri-implant bone loss. Int J Prosthodont 2006; 19: 560–566.
Clapp C, Wheeler J C, Martof A B, Levine P A . Oral squamous cell carcinoma in association with dental osseointegrated implants. Arch Otolaryngol Head Neck Surg 1996; 122: 1402–1403.
Block M S, Scheufler E . Squamous cell carcinoma appearing as peri-implant bone loss; a case report. J Oral Maxillofac Surg 2001; 59: 1349–1352.
Shaw R, Sutton D, Brown J, Cawood J . Further malignancy in field change adjacent to osseointegrated implants Int J Oral Maxillofac Surg 2004; 33: 353–355.
Abu El-Naaj I, Trost O, Tagger-Green N et al. Peri-implantitis or squamous cell carcinoma? Rev Stomatol Chir Maxillofac 2007; 108: 458–460.
Weitzman S A, Gordon L I . Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood 1990; 76: 655–663.
Jiiang-Huei J, Ying-Jan W, Bor-Luen C et al. Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-a production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis 2003; 24: 1301–1315.
Esposito M, Worthington H V, Coulthard P . Interventions for replacing missing teeth; treatment of peri-implantitis. Cochrane Database Syst Rev 2004; 4: CD004970.
McGregor D B, Baan R A, Partensky C, Rice J M, Wilbourn J D . Evaluation of the carcinogenic risks to humans associated with surgical implants and other foreign bodies – a report of an IARC Monographs Programme Meeting. Eur J Cancer 2000; 36: 307–313.
Czerninski R, Kaplan I, Almoznino G, Maly A, Regev E . Oral squamous cell carcinoma around dental implants. Quintessence Int 2006; 57: 707–711.
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Kwok, J., Eyeson, J., Thompson, I. et al. Dental implants and squamous cell carcinoma in the at risk patient – report of three cases. Br Dent J 205, 543–545 (2008). https://doi.org/10.1038/sj.bdj.2008.980
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DOI: https://doi.org/10.1038/sj.bdj.2008.980
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