Key Points
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Hyperzincaemia has been identified as a cause of copper deficiency which can result in anaemia and irreversible myelopathy.
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There are now a number of case reports of copper deficiency myelopathy secondary to overuse of zinc-containing denture adhesive.
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Even with copper supplementation, neurological damage due to copper deficiency may be permanent and so early detection and patient education is vital.
Abstract
Copper deficiency in humans can result in both anaemia and neurological symptoms affecting walking and balance. Recently zinc excess due to overuse of zinc-containing denture adhesive has been recognised as a potential cause of copper deficiency. Recovery from neurological symptoms with replacement therapy appears to be limited and so emphasis falls on education and early detection. Dentists are well placed to educate patients on use of denture adhesives and to detect early signs of copper deficiency in patients who may be using zinc-containing denture adhesive to excess. A case of a 58-year-old man diagnosed with copper deficiency myelopathy possibly due to zinc-containing denture cream overuse is presented.
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Doherty, K., Connor, M. & Cruickshank, R. Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy. Br Dent J 210, 523–525 (2011). https://doi.org/10.1038/sj.bdj.2011.428
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DOI: https://doi.org/10.1038/sj.bdj.2011.428
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