Table 3 Analysis of expression of different genes in total RNAs of control and knockout (KO) mice liver a

From: Inactivation of CBF/NF-Y in postnatal liver causes hepatocellular degeneration, lipid deposition and endoplasmic reticulum stress

 

2 weeks

3 weeks

4 weeks

Gene

Control

Knockout

Fold

Control

Knockout

Fold

Control

Knockout

Fold

GRP78

0.090 ± 0.0064

0.208±0.025

+2.31

0.283 ± 0.020

0.683 ± 0.101

+2.41

0.669± 0.142

0.516± 0.0732

−1.30 (NS)

ERP72

0.088 ± 0.00078

0.046±0.0072

−1.90

0.232 ± 0.0233

0.0853 ± 0.0112

−2.72

0.254±0.0312

0.0281± 0.00724

−9.04

PDI

2.445±0.095

1.823±0.151

−1.34

0.595 ± 0.0585

0.341 ± 0.0421

−1.74

2.520±0.256

0.760±0.105

−3.32

Pdia3

0.683±0.0404

0.597±0.0556

−1.14

0.603 ± 0.0248

0.431 ± 0.0447

−1.40

1.268±0.421

0.314±0.0721

−4.04

C/EBP α

0.0143± 0.00455

0.00619±0.00115

−2.31

0.0603 ± 0.00738

0.0275 ± 0.0115

−2.19

0.0619±0.0330

0.00947 ± 0.00277

−6.54

C/EBP β

0.0423± 0.00476

0.0329±0.00486

−1.28 (NS)

0.129 ± 0.0174

0.148 ± 0.0171

+1.14 (NS)

ND

ND

−

C/EBP δ

0.00329 ± 0.000226

0.00382 ± 0.000538

+1.16

0.00815 ± 0.000839

0.0112 ± 0.0023

+1.37

0.0102± 0.00180

0.0199± 0.00178

+1.95

PPAR γ

0.00963 ± 0.00106

0.0173±0.00385

+1.80

0.0264 ± 0.00505

0.0460± 0.0112

+1.74

0.0164±0.00761

0.0204± 0.00969

+1.24 (NS)

  1. aTotal RNA from 3 control and 3 knockout mice at each time point were used for the expression analysis by QPCR method. The Data presented is the mean and standard deviations. Fold differences for C/EBPβ at 2 and 3 weeks, GRP78 and PPARγ at 4 weeks are statistically not significant (P>0.05) as indicated by NS, whereas all the other fold differences are statistically significant (P<0.05). Expression of C/EBPβ at 4 weeks was not determined.
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