Figure 4 | Scientific Reports

Figure 4

From: Essential role of microfibrillar-associated protein 4 in human cutaneous homeostasis and in its photoprotection

Figure 4

Effect of MFAP-4 over-expression on the UVB-induced increase in MMP-12 activity.

(a) Luna staining was performed to evaluate the role of MFAP-4 in the protection of elastic fibers using paraffin-embedded sections from non-exposed skin with a control reporter gene over-expression, a control reporter gene-transduced skin with UVB irradiation for 8 wks and MFAP-4-over-expressed skin with repetitive UVB irradiation for 8 wks. Scale bars = 100 μm. (b) MMP-12 activities in xenografted human skins treated with lentiviral vectors encoding a control reporter gene with or without UVB irradiation for 8 wks and UVB-exposed skin with MFAP-4 over-expression were evaluated using fluorescent-tagged MMP-12 substrate as detailed in the Methods. The values reported represent means ± SD. **p<0.01; vs the value in UVB-exposed skin with a control reporter gene over-expression.

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