Figure 5
From: The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease
Reduced tyrosine hydroxylase induction in BACE1 null mice.
Tyrosine hydroxylase (TH) levels correlate with OSN input into glomeruli. Representative images of olfactory bulbs immunostained with an antibody recognizing TH (red) and a nuclear stain DAPI (blue) from a control BACE1 +/+ mouse (a), a BACE1 +/− mouse (b) and a BACE1 −/− mouse (c). Quantitation of the intensity of TH staining in glomeruli of BACE1 deficient mice (n = 4) and wild type littermate mice (n = 4) reveals a statistically significant difference (p < 0.05) between BACE1 +/+ and BACE1 −/− mice (d).
