Figure 2
From: Functional analysis of missense variants in the TRESK (KCNK18) K+ channel
Response of TRESK variants to ionomycin.
(A) Representative current responses to 500 nM ionomycin. Plotted current values represent measurements taken at the end of 300-ms voltage steps to −100 mV applied every 3 s from a 0-mV holding potential. As shown above the trace, oocytes were switched from lowK to highK solution prior to the application of ionomycin. (B) Normalised responses to ionomycin. The current measured after ionomycin activation was normalised to the current measured before activation in each oocyte. Oocytes were injected with 0.13 ng RNA. N-numbers are given within the bars.
