Figure 3
From: Functional analysis of missense variants in the TRESK (KCNK18) K+ channel
Loss of function in the A34V and C110R variants.
(A) Representative whole cell currents from an oocyte expressing a larger quantity of A34V mRNA (4.5 ng). (B) Representative current responses to 500 nM ionomycin of an oocyte expressing a larger quantity A34V mRNA (4.5 ng). (C) Normalised peak currents measured at +20 mV for WT TRESK coexpressed with either the A34V or C110R variants. Molar ratios, indicated above the bars, are 1∶1 = 0.45 ng:0.45 ng; 5∶5 = 2.5 ng:2.5 ng; 1∶5 = 0.45 ng:2.5 ng. N-numbers are given within the bars.
