Figure 2

(A) 3D structure-based NJ-phylogenetic tree (see Supplementary Information) of the CISM-enzymes nitrate reductase (Nar), DMSO/TMAO reductase (Dms/Dor/Tor), arsenate reductase (Arr), formate dehydrogenase (Fdh), arsenite oxidase (Aro) and polysulfide reductase (Psr).Violet and orange denote eury- and crenarchaeal branches, dark green, cyan and light green stand for Proteobacteria, Firmicutes and other Bacteria, respectively. Open and closed dots indicate bootstrap values for the deep branchings exceeding 70 and 90%, respectively. In 3D structures, the Mo-subunit is in violet. (B) Redox potential range of relevant substrates and corresponding enzymes.