Figure 2 | Scientific Reports

Figure 2

From: Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses

Figure 2

Pairing-induced LTD requires a calcium influx in the postsynaptic cell via voltage-dependent calcium channels.

(A) Averaged traces of MF-GPSC (30 to 60 trials including failures) evoked before and 20 min after pairing in control, in neurons loaded with intracellular BAPTA (20 mM) or exposed to nifedipine (10 μM). (B) Pairing-induced changes in the mean amplitude of MF-GPSCs in control (n = 44), in cells loaded with BAPTA (n = 13) or exposed to nifedipine (black column; n = 8).

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