Figure 2
From: TNF-α and TGF-β Counter-Regulate PD-L1 Expression on Monocytes in Systemic Lupus Erythematosus
PD-L1 surface protein on SLE APCs is differentially regulated by TNF-α and TGF-β.
(A) Control PBMC were treated for 24 hours. Expression of PD-L1 on CD14highCD11c+ monocytes was assayed by flow cytometry and is expressed as fold induction over untreated cells. (B) Induction of PD-L1 on monocytes in SLE PBMC treated for 24 hours or cultured in media alone. Induction of PD-L1 protein by cytokine treatments was tested for significance by the Wilcoxon signed-rank test. Results were derived from multiple independent experiments.
