Figure 5
Detection and isolation of TW295-type S. mutans strains from IBD patients.
(a) Detection frequency of CBP-encoding cnm gene expressing S. mutans in IBD patients and healthy subjects. Amomg 98 IBD patients, 56 were S. mutans positive (57.14%). (b) Detection frequency of various serotypes. Serotype k and f are very rare (2.3% + 3.5% = 5.8%) in healthy subjects compared with major serotypes, such as serotypes c and e. In contrast, the detection frequency of serotype k and f was dramatically higher (12.5% + 12.5% = 25.0%) than with serotypes c and e. (c) The frequency of specific strains of S. mutans that have both the cnm gene and a specific serotype (k or f) in IBD patients and healthy subjects. The detection frequency of such specific strains of S. mutans in IBD patients was dramatically higher than in healthy subjects (14.29% vs. 3.53%, respectively; odds ratio, 4.55, 95%; confidence interval, 1.87–11.09; p = 0.0012).
