Figure 6
Specific strains of S. mutans isolated from IBD patients aggravate the colitis.
(a) Typical photos of whole mice administered isolated S. mutans. Sm-IBD 8 was isolated from patient 8 and Sm-IBD 21 from patient 21 in Supplementary Table 2. (b) Typical microscopic image of the colon of Sm-IBD8-infected mice on day 10. Mucosal damage and infiltration of inflammatory cells were observed in Sm-IBD 8-infected mice. (c) DAI of isolated S. mutans strains from IBD patients. Each column represents the mean ± SEM from 10–12 different animals. Statistical significance was determined using Bonferroni’s method after ANOVA. *p < 0.05. (d) Survival rate of isolated S. mutans strains from IBD patients. Each column represents the mean from 10–12 different animals.
