Figure 5

Levels of activation markers are similar between LMP2A transgenic mice and litter mate controls.
T cells purified from TCRMOG mice and B cells purified from LMP2A-BCRMOG (LMP2A) and WT-BCRMOG control (WT) mice were co-cultured with the indicated concentrations of rMOG. Expression of MHCII, CD80 and CD86 on B220+ cells (a) and CD25, CD44, CD62L and CD69 on CD3+ cells (b) were evaluated after 24 hour of culture using flow cytometry.