Figure 6

Effects of metformin on the radiosensitivity of CSCs or CS-like cells.

(A) MCF-7 cells were irradiated, incubated with or without 1 mM metformin for 48 h and analyzed for CD44^high/CD24^low cells. (B) % of CD44^high/CD24^low MCF-7 cells after irradiation and 48 h incubation with 1 mM metformin. Means of 5 experiments ± 1 S.E. *P < 0.05 for IR-induced increases. **P < 0.05 between IR and IR + Metformin. (C) % of ALDH1-positive FSaII cells after irradiation and 48 h incubation with 1 mM metformin. Means of 5 experiment ± 1 S.E. *P < 0.05 for IR-induced increases. **P < 0.05 between IR and IR + 1 mM Metformin groups.