Figure 2
From: Calcineurin Controls Voltage-Dependent-Inactivation (VDI) of the Normal and Timothy Cardiac Channels
Cyclosporine A (CsA) increases VDI of Cav1.2.
(a) Normalized IBa and ICa records from representative oocytes expressing Cav1.2 (wt) in the presence of 2 µM CsA (ICa) (left), or 0.6 and 2 µM of CsA (IBa)(right). (b) The voltage-dependence of Cav1.2 inactivation in the presence or absence of CsA (protocol in Fig 1d). Normalized ICa (left) and IBa (right) were fitted to the Boltzmann equation. Values are displayed as mean ±S.E.M (n = 10−12). Peak currents for: ICa, α11.2, −700 ± 57 nA (n = 13); α11.2 +2 µMCsA, −625 ± 76 nA (n = 12); IBa, α11.2, −774 ± 34 nA (n = 10) ;α11.2 +2 µMCsA, −670 ± 69 nA (n = 8).
