Table 1 Steady-state inactivation parameters of wt CaV1.2 and TS channel CaV1.2G406R
From: Calcineurin Controls Voltage-Dependent-Inactivation (VDI) of the Normal and Timothy Cardiac Channels
Charge Carrier | Alpha subunit | Cmax (%) | V1/2 (mV) | n | p value |
|---|---|---|---|---|---|
Ca 2+ | α11.2 | 95±3.3 | −30.6 ± 2.1 | 10 | |
α11.2/A1929P | 93±3.2 | −25.8±3.8 | 9 | ||
α 11.2/HH/AA | 99±2.6 | −30.5±1.6 | 8 | ||
α 11.2 /G406R | 38±4.3 | −30.2 ± 1.5 | 10 | ||
α 11.2/G406R + 0.05 µM CsA | 76±6.0 | −75.7 ± 33.1 | 8 | < 0.005 | |
α 11.2/G406R/A1929P | 71±2.9 | −9.9 ± 1.5 | 8 | < 0.005 | |
α 11.2/G406R/HH/AA | 77±4.5 | −21.1 ± 2.2 | 8 | < 0.005 | |
Ba 2+ | α 11.2 | 58±2.4 | 1.34 ± 2.4 | 14 | - |
α11.2/A1929P | 91±3.2 | −12.1 ± 3.6 | 8 | ||
α 11.2/HH/AA | 91±3.5 | −1.1 ± 3.3 | 21 | < 0.005 | |
α 11.2/G406R | 29±2.2 | −30.3 ± 3.5 | 10–12 | - | |
α11.2/G406R/A1929P | 61±5.0 | −14.1 ± 5.5 | 13 | < 0.005 | |
α 11.2/G406R/HH/AA | 61±1.1 | −17.4 ± 9.2 | 12 | < 0.005 | |
α 11.2/G406R + 0.08 µM CsA | 63±4.8 | −44.8 ± 5.4 | 8 | < 0.01 |
