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Figure 1

From: TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

Figure 1

TRPA1 agonist allyl isothiocyanate (AITC) and carrageenen (Car) induced an inflammatory paw edema, which could be prevented by pre-treatment with HC-030031 (HC) or ibuprofen (Ibu.).

HC-030031 (300 mg/kg) or ibuprofen (100 mg/kg) was injected intraperitoneally 2 h prior to intraplantar injection of carrageenan or AITC into the hind paw. The edema was measured 3 h and 6 h after intraplantar injection and compared to the basal level. The contralateral control paw injected with saline developed no measurable edema. Mean + SEM, n = 6, ***p<0.001.

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