Figure 1
From: Hair organ regeneration via the bioengineered hair follicular unit transplantation
Ectopic regeneration of a hair follicle via transplantation of a bioengineered hair follicle germ.
(a) A schematic representation of the method for regenerating the hair follicle via transplantation into the sub-renal capsule (SRC). (b) Morphologic and histological analysis of the bioengineered hair follicle germ. Phase contrast photographs of a hair follicle germ at 0 hr and 2 days after cultivation (left two panels). The dotted lines indicate a boundary between the epithelial and mesenchymal cells in the OC (organ culture) at 0 hr and day 2. Macro-morphological observations of the bioengineered hairs at 14 days after transplantation into the sub-renal capsule (right panel). (c) Histological analysis of the bioengineered hair follicles. The boxed area shows high-magnification in the right two panels. ad, adipocyte; cys, cyst; dp, dermal papilla; hs, hair shaft; irs, inner root sheath; ors, outer root sheath; sg, sebaceous gland. (d) Microscopic observations of the ectopically bioengineered hair shafts classified as awl, zigzag or unclassified hairs. The percentage of regenerated hair types (right). Bars represent standard deviations. (e) A comparison of the length of the hair follicle and the bulb between the natural and regenerated awl hairs.
