Table 1 Biochemical measurements in plasma and feces of control and Colestilan-treated TGR5+/+ and TGR5−/− mice

From: TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

 

TGR5 +/+

TGR5 +/+

TGR5−/−

TGR5−/−

 

Control

Colestilan

Control

Colestilan

Final body weight (g)

58.94 ± 0,93

53.84 ± 0,77a

58.61 ± 1,94

53.71 ± 2,09a

Plasma

    

 LDL-cholesterol (mM)

0.42 ± 0.02

0.35 ± 0.03a

0.39 ± 0.05

0.32 ± 0.03

 HDL-cholesterol (mM)

4.50 ± 0.16

4.43 ± 0.21

4.49 ± 0.22

4.22 ± 0.19

 Total cholesterol (mM)

5.48 ± 0.14

5.19 ± 0.20

5.55 ± 0.32

5.03 ± 0.24

Feces

    

 Fecal weight (mg/day/g BW)

12.30 ± 3.54

33.08 ± 3.23a

11.87± 2.35

30.39 ± 4.23a

 Glycerol derivatives (μg/mg)

0.18 ± 0.02

0.58 ± 0.09a

0.24 ± 0.03

0.60 ± 0.09a

 Total cholesterol (μg/mg)

3.88 ± 1.23

4.23 ± 0.91

3.23 ± 1.78

3.98 ± 1.23

 Free fatty acids (μg/mg)

5.45 ± 1.56

10.34 ± 2.34a

6.23 ± 1.34

11.19 ± 3.29a

 Phospholipids (μg/mg)

3.39 ± 0.62

7.98 ± 1.92a

11.13 ± 3.23b

9.29 ± 0.43

 Total bile acids (μmol/g)

4.09 ± 1.10

10.29 ± 0.98a

2.22 ± 0.34b

6.87 ± 1.23a,b

  1. Colestilan 2% was supplemented in the diet for 2 weeks after 12 weeks of high fat feeding. Values represent mean ± SE.
  2. aStatistically significant as compared to corresponding control group, p<0.05.
  3. bStatistically significant between genotypes, p<0.05.