Figure 8
From: Environmental conditioning in the control of macrophage thrombospondin-1 production
TSP-1 expression during acute inflammation experimental autoimmune uveoretinitis.
(A) Clinical EAU assessed by TEFI was slightly advanced compared to the WT control group. The peak of clinical disease ant the kinetics of disease in the first 30 days were similar. (B) Infiltrating macrophages (CD11b+ cells) expressed low levels of TSP-1 at day 26. (C) Infiltrating T cells stimulated with PMA/Ionomycin produced comparable levels of IFNγ and IL-17 at day 26. Disease scores for WT and TSP-1 KO mice up to day 32. n = 10 per group. Cytokine measurements average of cells from 7-8 individual eyes from two independent experiments.
