Figure 5
From: The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice
JUN controls BIM expression after axonal injury.
(A) JUN, which is known to control RGC death after CONC, is expressed by one day after injury, prior to BIM expression. By 3 days after CONC, RGCs coexpress JUN and BIM. (B) In contrast to the robust BIM expression (red) seen after CONC in RGCs of Jun+/+ mice, there is no BIM expression in Jun deficient RGCs (Junf/f; Six3-cre). Thus, JUN appears to control BIM expression after axonal injury. Similar results were obtained from at least 3 different mice for each time point and genotype. DAPI, blue; Scale bar, 25 μm.
