Figure 1

Network diagram of canonical gene regulatory circuit of two mutually opposing proteins that positively self-regulate themselves.

Two types of genes, A and B are translated into proteins A and B respectively. The proteins A(B) can bind to the promoter of the gene A(B) to activate the synthesis rate of A(B), which makes a self-activation feedback loop. The proteins A(B) can bind to the gene B(A) to repress the synthesis rate of B(A), which makes a mutual repression loop. Both protein A and protein B bind to promoters as a dimer with the binding rate respectively and the unbinding rate f_αA, f_αB respectively, with α = (A, B).