Table 1 Largest structural damages produced in metabolism by gene knockouts and correspondence with gene essentiality as given in Ref. (25). Damage in metabolic structure caused by gene knockout (third column) is measured in number of deleted reactions. In the fourth column, we give the number of reactions regulated by the corresponding gene and in parentheses we give the damage associated to each of these reactions. Genes in monocomponent clusters are highlighted in boldface and we used braces to denote genes that form complexes. Note that the complex at the end of the list is not detected by any of the three clustering procedures. Finally, gene mpn062 is the only one in the table annotated as non-essential although it is associated to a large failure cascade

From: Predicting effects of structural stress in a genome-reduced model bacterial metabolism