Table 2 Summary of genetic association studies of schizophrenia for the CACNA1C polymorphism rs1006737

From: Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals

  

Genotype counts (AA/AG/GG)

Allele frequency (A-allele)

 

n (SZ/CON)

SZ

CON

χ2 P-value

SZ

CON

χ2 P-value

OR (95%CI)

The present study

552/1132

2/70/480

3/127/1002

0.36 5

0.067

0.059

0.35

1.15 (0.86–1.54)

Green et al. (2010)1

479/11361

66/208/205

1252/4949/5160

0.034

0.355

0.328

0.083

1.15 (0.99–1.32)

Nyegaard et al. (2010)2

976/1489

130/444/402

158/675/656

0.015

0.361

0.333

0.044

1.13 (1.003–1.275)

Bigos et al. (2010)3

282/440

NA

NA

0.03

NA

NA

NA

NA

Zhang et al. (2012)4

318/401

NA

NA

> 0.05

NA

NA

NA

NA

  1. Abbreviations: SZ, schizophrenia patients; CON, control individuals; CI, confidence interval; OR, odds ratio; NA: not available.
  2. 1P-value for allele frequency was calculated based on their data.
  3. 2P-value for allele frequency, odds ratio and its 95% confidence interval were calculated based on their data.
  4. 3Odds ratio (95% confidence interval) for A-allele homozygotes was reported to be 1.77 (1.07–2.91).
  5. 4Detailed data are not presented in this report.
  6. 5P-value was calculated after combining AA and AG genotypes as a group.
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