Table 3 Demographic and clinical variables of schizophrenia patients and healthy controls included in the cognitive experiment, stratified by the CACNA1C rs1006737 genotype
| Â | Schizophrenia patients (n = 202) | Healthy controls (n = 706) | ||||||
|---|---|---|---|---|---|---|---|---|
Characteristics | AG+AA (n = 31) | GG (n = 171) | Statistics | P-value | AG+AA (n = 87) | GG (n = 619) | Statistics | P-value |
Age, years: mean ± SD | 40.9 ± 13.1 | 42.0 ± 13.2 | t = 0.40 | 0.69 | 46.7 ± 16.0 | 44.1 ± 15.4 | t = 1.47 | 0.14 |
Gender, female: n (%) | 12 (38.7) | 64 (37.4) | χ2 = 0.02 | 0.89 | 65 (74.7) | 455 (73.5) | χ2 = 0.06 | 0.81 |
Education, years: mean ± SD | 13.1 ± 2.2 | 13.0 ± 2.7 | t = 0.12 | 0.90 | 15.0 ± 2.9 | 15.1 ± 2.7 | t = 0.35 | 0.72 |
Family history of any psychiatric disorder: yes, n (%) | 14 (45.2) | 72 (42.1) | χ2 = 0.10 | 0.75 | 12 (13.8) | 84 (13.6) | χ2 = 0.003 | 0.95 |
Age at onset, years: mean ± SD | 23.2 ± 9.0 | 24.0 ± 8.4 | t = 0.51 | 0.61 | NA | NA | NA | NA |
Duration of illness, years: mean ± SD | 18.8 ± 12.0 | 17.7 ± 11.9 | t = 0.45 | 0.65 | NA | NA | NA | NA |
Outpatients/inpatients: n (%) of outpatients | 23 (74.2) | 133 (77.8) | χ2 = 0.19 | 0.66 | NA | NA | NA | NA |
Number of hospitalisations: mean ± SD | 3.0 ± 3.3 | 2.3 ± 2.4 | t = 1.40 | 0.16 | NA | NA | NA | NA |
Lifetime ECT: yes, n (%) | 2 (6.5) | 22 (12.9) | Fisher's exact | 0.54 | NA | NA | NA | NA |
Medication dosage1, mg/day: mean ± SD | 913.4 ± 685.7 | 711.2 ± 658.8 | t = 1.51 | 0.13 | NA | NA | NA | NA |
PANSS positive score2: mean ± SD | 12.5 ± 7.0 | 13.4 ± 5.4 | t = 0.65 | 0.51 | NA | NA | NA | NA |
PANSS negative score2: mean ± SD | 17.7 ± 7.9 | 18.3 ± 7.7 | t = 0.31 | 0.76 | NA | NA | NA | NA |
PANSS general psychopathology score2: mean ± SD | 27.2 ± 7.2 | 29.2 ± 8.5 | t = 1.04 | 0.30 | NA | NA | NA | NA |
