Table 1 Top 30 genes with promoters differentially methylated in control and miR122-silenced Huh7 cells. Values indicate methylation levels. Values in ‘Differences’ indicate quantitative differences in methylation levels of target gene CpG sites. Higher values indicate greater methylation levels. Genes in bold and highlighted in gray means greater methylation; others were less methylated in miR122-silenced Huh7 cells

From: Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation

SYMBOL

Control

miR122-silenced

Difference

CpG ISLAND LOCATIONS

GPC3

0.4242135

0.11596

0.3082535

X:132946499-132947763

FLJ30058

0.4155016

0.1428133

0.2726883

X:130019792-130020537

EIF3S6IP

0.672594

0.4012034

0.2713906

22:36574299-36576077

BHLHB9

0.3481071

0.07687688

0.27123022

X:101862184-101862707

PORCN

0.6389685

0.3697215

0.269247

 

MSI2

0.4593301

0.1955636

0.2637665

17:52688030-52689554

DNTT

0.6114385

0.3489618

0.2624767

10:98054238-98054478

SEMA3B

0.3901392

0.1301293

0.2600099

3:50285369-50286362

RYR2

0.4331115

0.1756537

0.2574578

1:235271651-235273428

TCEAL7

0.6519198

0.4006093

0.2513105

 

NR0B2

0.3711949

0.1234481

0.2477468

 

SOCS3

0.1831344

0.4273662

0.2442318

17:73866027-73868731

TAS2R16

0.5821649

0.3380581

0.2441068

 

BHLHB9

0.3021148

0.06171004

0.24040476

X:101862184-101862707

OR12D3

0.5266486

0.2884241

0.2382245

 

ADAMTSL1

0.4537211

0.2196532

0.2340679

 

TBX6

0.5031447

0.2695281

0.2336166

16:30010427-30011656

ICAM4

0.4990334

0.2668367

0.2321967

19:10258558-10259935

C9orf125

0.2387415

0.4707038

0.2319623

9:103287963-103289481

ELN

0.1332373

0.3629701

0.2297328

7:73080116-73080605

ANKRD30A

0.898423

0.6711555

0.2272675

10:37453955-37454965

OR10J1

0.5324367

0.3094136

0.2230231

 

TP73

0.3596564

0.1386476

0.2210088

1:3596889-3597535

CNNM1

0.6313883

0.4106784

0.2207099

10:101078809-101080801

DHH

0.2955738

0.07619943

0.21937437

12:47774151-47774653

CTAG2

0.5303309

0.3110451

0.2192858

X:153536438-153536702

GNB4

0.3091451

0.09039365

0.21875145

3:180651316-180652496

PNPLA2

0.4458646

0.2272328

0.2186318

11:808884-809164

FGF7

0.6298472

0.4128944

0.2169528

 

NTE

0.4557684

0.2400911

0.2156773

19:7504300-7507429

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