Figure 1
From: Nitric oxide rescues thalidomide mediated teratogenicity
Nitric oxide recovers the thalidomide teratogenic effects.
(A) Chicken embryos (n = 160 eggs) were treated with 40 μg of thalidomide at HH stage 8 followed by treatment with various concentrations of spNO (0.001 μM – 100 μM). An addition of 10 μM spNO after 30 min of thalidomide treatment could neutralizes the thalidomide teratogenic effect up to 94 %. **p<0.01. (B) In another set of experiments, embryos were treated with 40 μg of thalidomide followed by addition of spNO at different times (0, 0.5, 1, 6, 12, 24 and 144 h) after adding thalidomide. **p<0.05 vs vehicle control; #p<0.01 vs 1 μM.
