Figure 7
Long-term potentiation in the hippocampus of GM-CSF ko animals.
(A) LTP at CA3 Schaffer collaterals in the CA1 dendritic region was induced using a delta burst protocol at timepoint 0 min and monitored for 60 min after induction. Shown are population spike amplitudes as means ± SEM (wt, n = 21 slices; GMko, n = 23 slices; n = 8 mice each). GMko mice do not show impaired LTP induction when comparing the last 10 min of the protocol. Insets depict individual traces of wt and ko animals prior and after LTP induction. WT, n = 21; KO, n = 23 slices; 8 animals each. Data is presented as mean ± SEM. (B) Input-output relation of electrical stimulation at the Schaffer collaterals. Shown are mean values of population spike amplitude and SEM of wild type (black) and knock out (red) at different stimulation strengths.
